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Name: Trimethyl(trifluoroMethyl)silane
CAS number: 81290-20-2
Molecular formula:C4H9F3Si
Molecular weight: 142.2 g/mol
Purity: ≥99%
Appearance: Colorless transparent liquid
Boiling point: 53-55°C, @760mmHg
Density: 0.969 g/ml, @25 °C (lit.)
Stability: volatile
Storage: sealed at room temperature
Uses: trifluoromethylation reagent.
Packing:1KG;5KG;25KG;50KG;100KG;200KG
Application reference:
Trifluoromethyl is widely used in pharmacochemistry. Fluoxetine, developed by Lily, is the world's first listed SSRIs antidepressant drug. Due to the introduction of trifluoromethyl, Fluoxetine has unique pharmacological properties and clinical efficacy, and is favored by doctors and patients. Trifluoromethyl has the following properties:
1) Trifluoromethyl is the most lipophilic group among all substituents;
2) Due to its strong electronegativity and high stability, trifluoromethyl plays a decisive role in the regional and stereoselectivity of the biological and chemical transformation of the substrate;
3) It is particularly worth mentioning that many organic molecules containing trifluoromethyl have important physiological activities.
According to the reaction mechanism, the introduction of trifluoromethyl can be divided into three main categories: free radical trifluoromethyl, nucleophilic trifluoromethyl and electrophilic trifluoromethyl.
